Abstract Library

#1150 Platelet Serotonin But Not Dopamine Concentrations Are Lower in Pancreatic Neuroendocrine Tumor and Renal Cell Carcinoma Patients Compared to Healthy Individuals.

Introduction: Platelets carry VEGF-A, serotonin and dopamine. Serotonin stimulates and dopamine inhibits tumor angiogenesis. We hypothesized that platelets are activated in tumor vasculature and release angiogenic factors, resulting in lower platelet serotonin and dopamine.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Peters M, Van Faassen M, Van Asselt S, Bouma G, Meijer C,

Keywords: Serotonin, dopamine, pancreatic neuroendocrine tumor, renal cell carcinoma.,

#912 Serial 89Zr-bevacizumab PET in Patients with Neuroendocrine Tumors before and on Everolimus Treatment

Introduction: Everolimus increases PFS in patients with advanced NETs. Currently, no biomarkers are available for early selection of patients who will benefit from everolimus. Everolimus can reduce VEGF-A production by tumor cells.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Brouwers A, Van Asselt S, Oosting S, De Jong J, Lub-de Hooge M,

Keywords: neuroendocrine tumors, 89Zr-bevacizumab PET, VEGF-A, everolimus, biomarker,